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Seek medical attention if you experience extreme thirst with massive urine output (possible diabetic emergency), dark urine despite adequate fluid intake, pain or burning during urination, blood in urine, sudden decrease in urine output, or if increased urination persists beyond 12 weeks without improvement
This is especially dangerous for people with type 2 diabetes who may already be taking other medications like metformin or insulin
Interactions CYP: In vivo, one study reported increased or decreased expression of different isoforms (Olsozowy 2006)
After dosing, wait 30 minutes before brushing