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Given that both SGLT2i and GLP-1 RA demonstrate robust and consistent cardio-renal benefits [14], both agents seem to be an attractive option to fulfil an unmet therapeutic need in type 1 diabetes

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After washing with PBS (3 5 min), sections were incubated with species-matched Alexa Fluor-conjugated secondary antibodies (1:500, Invitrogen) for 2 h at RT protected from light

4a,b, Ki67-positive -cell ratio was significantly increased only in combination therapy in an early phase of diabetes, while no difference was observed in an advanced phase of diabetes (Fig

912 As these treatments are often prescribed for long-term use and are increasingly used for off-label indications, a clear understanding of their GI safety profiles is crucial for informed clinical decision-making