Chronic myeloid leukemia, polycythemia vera, and hypereosinophilic syndrome are the classic associations, and the mechanism is thought to be overproduction of haptocorrin or transcobalamin by the expanded cell population
Crucially, this happens without IGF-1 stimulation
Effective treatment of cobalamin deficiency with oral cobalamin
Salinas et al 27 The traditional treatment of vitamin B 12 deficiency is the intramuscular injection of cyanocobalamin, generally, 1 mg/d for 1 week, followed by 1 mg/wk for 1 month, and then 1 mg every 1 or2 months ad perpetuum
Unlike vitamin B12 supplements, B complex supplements contain a blend of multiple B vitamins, including vitamin B12
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