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The weight loss effects observed with these medications result from both delayed gastric emptying and direct effects on appetite centers in the hypothalamus, leading to reduced hunger and increased satiety

The pulse-and-decay profile lasts roughly 3-4 hours in published pharmacokinetic studies

We defined index date as the date of first pharmacy fill of either GLP1-RA or DPP4i, and operated under the assumption that patients are taking the prescribed medication as directed

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