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It depends on both copper and zinc as cofactors, but only copper regulates its activity ( 2 O 2 , CuZn-SODs activity is suppressed, via oxidation of His-118 to form 2-oxo-histidine (Uchida and Kawakishi, 1994)
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In a study in identical twins, discordant for type 2 diabetes (at the time of investigation), only the diabetic twin had decreased GLP-1 secretion (299)
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Glutathione steps in to help promote healthy estrogen levels, mitigating the risk of conditions such as polycystic ovarian syndrome (PCOS) and endometriosis (4)
For this reason, researchers sometimes refer to glutathione as the detox molecule. 12 Lu SC
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