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Elevated concentrations impair mitochondrial function by depleting CoQ10, reducing ATP production, and increasing ROS generation (e.g., HO, O) [15]
This avoids potential interactions between the copper peptide and retinoid in the same application
(1998) Ipamorelin, the First Selective Growth Hormone Secretagogue Eur J Endocrinol 139(5):552561
Platforms like ProteinQure have leveraged this approach to advance PQ2033, a peptide-drug conjugate now in clinical development [292]
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