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COP1 and DET1 cooperate to promote polyubiquitination of c-Jun The role of the RING finger in COP1 has been intriguing, as it can independently bind E2 enzymes 51,52 , making it appear as a redundant subunit within the CULLIN4 DET1-COP1 complex

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Sidaks multiple comparison tests did not show a significant change in marble burying in the vehicle treated mice (p = 0.97) or MT-II treated mice (p = 0.94)

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