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The strongest evidence for heart protection currently comes from: Semaglutide (Ozempic, Wegovy) Dulaglutide (Trulicity) Liraglutide (Victoza) In fact, the FDA has specifically approved Dulaglutide and Semaglutide to reduce the risk of major cardiovascular events in certain high-risk adults
Statistical analyses Estimating effects of semaglutide on the circulating proteome Linear regression was used to test for effects of treatment with semaglutide 2.4 mg relative to placebo on the change from baseline in relative protein concentration at week 68
Established CV data / high ASCVD risk: Semaglutide has robust cardiovascular-outcomes trials in T2D
Variants in GLP1R , GIPR (notably rs1800437), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) relate to different response patterns to semaglutide and tirzepatide
This trial showed noninferiority and superiority to semaglutide for HbA1c reduction, as well as for weight reduction
It can reduce fat causing a double chin
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