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Allison Whitten AstraZeneca reports mixed Phase 3 results across oncology and rare disease AstraZeneca reported mixed late-stage clinical results, with its Claudin 18.2-targeting antibody-drug conjugate sonesitatug vedotin meeting its primary endpoint in patients with previously treated advanced gastric cancer, while rare disease therapy Ultomiris missed the primary endpoint in a Phase 3 trial for thrombotic microangiopathy following haematopoietic stem cell transplantation (HSCT-TMA)

Starting at the low end (50 mg) is recommended to assess individual tolerance before escalating dose [4]

Our identification of VRK2-mediated SLC7A11 trafficking suggests a potential immune evasion mechanism, as SLC7A11-high tumors often display T cell exclusion phenotypes [37], warranting future investigation into whether VRK2 expression could predict therapeutic response to combined ferroptosis inducers and immune checkpoint inhibitors

Retrieved 10 October 2017

The mechanism of action of tirzepatide does not suggest a biological pathway that would directly cause lymph node enlargement