By stimulating pro-inflammatory and pro-thrombotic factors, it contributes to the development of several chronic diseases, including ischemic heart disease, cardiomyopathy, cardiac arrhythmias and chronic kidney disease
Minerva Endocrinology, 50(3), 296301
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The stability of tight junctions between endothelial cells is guaranteed by interactions with pericytes (Jo et al., 2013), and by Wnt proteins, vascular Endothelial Growth Factor (VEGF), and Transforming Growth Factor- (TGF-), released by astrocytes (Gurit et al., 2021
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Hydration becomes critical when experiencing diarrhea, as you lose both fluids and electrolytes