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Patients should report concerning symptoms including persistent fatigue beyond what is expected from thyroid disease, numbness or tingling in extremities, or cognitive changes, which warrant immediate medical evaluation and potential B12 supplementation
Semaglutide could become a part of a broader treatment plan that includes diet, exercise, and other medications tailored to each patients needs
The side effect profile, which includes significant nausea, GI disturbance, and muscle mass loss alongside fat loss, is the tradeoff
Conclusion Drug metabolism is very significant in controlling the pharmacokinetics
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