The result is elevated blood glucose, increased cardiometabolic risk, andif not addressedcomplications affecting the eyes, kidneys, nerves, heart and circulation
The TRIUMPH-4 trial protocol provides the best reference for effective dosing : Weeks 1-4: 2 mg once weekly (starting dose) Weeks 5-8: 4 mg once weekly Weeks 9-12: 6 mg once weekly Weeks 13-16: 8 mg once weekly Week 17+: 9 mg or 12 mg once weekly (maintenance dose) The escalation happens every 4 weeks, which is slightly faster than many tirzepatide protocols
Handy DE, Zhang Y, Loscalzo J
The target temperature range is incredibly important
10.3390/pharmaceutics13050648 23 ElsheikhM
Cuando tirzepatida se aade a un tratamiento previo con sulfonilurea y/o insulina, se puede considerar una reduccin de la dosis de sulfonilurea o insulina para reducir el riesgo de hipoglucemia