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A 2025 Bayesian network meta-analysis placed retatrutide in comparative context against mono-agonists and dual agonists for weight-loss outcomes in non-diabetic populations (PMID 40685589)

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Before treatment, his CGM showed: frequent glucose spikes after meals a persistently elevated baseline glucose , even between meals and overnight This pattern suggests prolonged glucose exposure and repeated insulin demand throughout the day

"I think one of the things that needs to be understood is that a GLP-1 agonist, whether it's for weight loss or diabetes, it is meant to be on for a while, this is a long-term therapy

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