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Interestingly, these genes were critical components of phase I/II metabolism ( CYP1A5, CYP2H1, CYP2K1, CYP2F3 , etc), antioxidant enzymes ( GST1/3/K1 ), fatty acid metabolism ( ACAA1, ACOX1, ACAT1, FADS1, FASN, HADH , etc), apoptotic genes ( CASP3, CBR1, CCBL1, PPIF, KRT18 , etc), protein kinases ( PLK2 ), oxidative responsive genes ( AKR1A1, AR, AO, FMO3, GPX4, NQO1, TXN, TDO2 , etc), cell cycles and cancer-associated genes ( PRELID1, PLK2, UGT1A8, MDM2 ) (308)

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