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Skin reactions such as rash, hives, or itching may occur in sensitive individuals

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Parmentier, C., Leroy, P., Wellman, M

Owing to insidious symptoms and the lack of highly sensitive and specific biomarkers, the diagnosis of precancerous or cancerous esophageal lesions is primarily based on endoscope-based pathologic changes, which are expensive, painful, and often cause late diagnosis

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