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Participants treated with all doses of oral semaglutide experienced greater reductions in FPG and 7-point SMPG than those treated with sitagliptin 100 mg

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In vitro signaling studies demonstrated that tirzepatide was able to activate the GIP receptor with comparable potency to native GIP ( in vitro and in vivo models used, tirzepatide was able to stimulate glucose-dependent insulin secretion via GIP and/or GLP-1 receptor activation