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Collectively, hyperglycemia or obesity impairs skin T cell proliferation and function via STAT5, aryl hydrocarbon receptor (AHR) signaling, mTOR, the IL-15IGF-1 loop, and other pathways (22, 113, 116, 118) ( Table 4 )
IGF-DES shares the mitotic risks of all IGF-1 analogs but has a distinct metabolic safety profile due to its short half-life
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The dental team may need to adjust instructions or timing to keep patients safe and comfortable