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Metformin has been around longer
Tolerability: Tolerability: While the side effect profile of incretin mimetics is relatively mild (low rates of severe AEs
It offers hope for low ovarian reserve
As shown in Scheme 25
2 Establishes GLP-1RAs are engineered to overcome the rapid degradation of native GLP-1 through DPP-4resistant modifications and exposure-extending strategies such as fatty-acid acylation, enabling sustained receptor occupancy
both have high energy demands due to continuous activitycardiomyocytes for rhythmic contractions and neurons for electrical and chemical signalingand are post-mitotic, making them reliant on mitochondrial quality control as they cannot replace damaged mitochondria through cell division
