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HW TIPS TO MINIMIZE GI SIDE EFFECTS One or more gastrointestinal (GI) side effects are observed in roughly 10% to 50% of people who take one of these weight management medications.1,2 From nausea and vomiting to acid reflux, bloating, stomach cramps, diarrhea, and/or constipation, patients can minimize GI side effects with a start low, go slow approach, starting with the lowest dose and titrating as recommended (see table Currently FDA-Approved Mono and Dual Agonists)

The result is a significant, sustained reduction in hunger that makes caloric reduction far easier than traditional dieting

Gradual potency loss Days 1-28: Minimal degradation

However, other researchers have argued that controversial issues exist because GPNA also inhibits other glutamine transporters, such as SLC38A1, and V-9302 is effective even in SLC1A5 knockout models 206,207

doi: 10.1007/s40123-023-00702-3 217 AllenRSHanifAMGogniatMAPrallBCHaiderRAungMHet al

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