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Current laboratory investigations further evaluate intracellular signaling involving TGF- , MAPK/ERK , PI3K/Akt , NF-B , matrix metalloproteinases (MMPs) , tissue inhibitors of metalloproteinases (TIMPs) , copper-dependent enzymes, and additional molecular systems associated with extracellular matrix regulation and peptide signaling

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Distinct from classical GH signaling (experimental): Research suggests minimal stimulation of IGF-1 and limited activation of pathways typically driven by full-length growth hormone