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Several studies have indicated that the presence of S aggregates in the gut can spread out to the brain via the vagus nerve ( S has a high binding affinity for pre-synaptic vesicles and its accumulation in pre-synaptic terminals is a sign of synaptopathy

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This dual improvement in glucose and lipid homeostasis suggests potential applications in research focusing on insulin sensitivity and fatty liver prevention

It inhibits NNMT, the enzyme that methylates nicotinamide and diverts it away from NAD+ production

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