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mTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT

Reference articles Zouboulis CC, Benhadou F, Byrd AS, et al

A 2006 paper in the Journal of Clinical Endocrinology and Metabolism reported a Phase 1/2 trial documenting prolonged GH and IGF-1 stimulation by CJC-1295 in healthy adults (PMID 16352683)