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However, these findings are mostly limited to single models, lacking data on distinct DR stages, ocular targeted delivery, long-term safety and efficacy, and comparisons with first-line clinical therapies
Ethics declarations Competing interests The author declares associations with the following companies: Astra-Zeneca, Bristol-Myers Squibb, Merck Sharpe & Dohme, NovoNordisk and Sanofi-Aventis (advisory board membership
The larger sample size and longer duration provide robust evidence of sustained efficacy
In pathophysiological states, including increased insulin resistance, the hybrid receptor number is changed significantly, thus potentially abrogating the chance for IGF-1 to alter glucose metabolism [129, 132, 133]
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