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Despite the development of GLP-1 monoagonists, new peptides that combine the pharmacology of GLP-1 with other gut peptides increase the efficacy of these agonists while reducing their dose-related gastrointestinal side effects
[6] [7] These medications are contraindicated during pregnancy and require discontinuation before planned conception (typically 2 months for semaglutide and 1 month for tirzepatide)
Rotate injection sites each time to prevent lipohypertrophy (fatty lumps under the skin)
An up-regulation of GLUT4 during adipogenesis improves insulin-dependent glucose uptake, which is required for lipids storage in adipocytes
doi: 10.1016/j.diabres.2021.108998 39 KaaksRLukanovaA
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