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Subsequently, transmission electron microscope (TEM) observations showed that LPS treatment led to mitochondrial shrinkage, increased membrane density and reduced volume, and 2,3-cGAMP further aggravated this pathological change, while C-176 or GLP-1RAs could effectively alleviate the above-mentioned mitochondrial damage (Fig

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550 In Phase II trials (KARDIA-1), zilebesiran reduced systolic blood pressure in all treated patients, with effects lasting 6 months, opening new possibilities for NADs use in treating hypertension and CVDs