For example, niches may be created by addressing specific unmet needs in certain patient types (e.g., patients who prefer not to inject, or who failed prior lines of GLP-1s), or by addressing specific access issues (e.g., developing a lower-cost option, securing broader payer coverage)
and (2) the incidence and pathophysiology of cutaneous adverse events associated with their use
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After NSAIDs or insulin overdose or cuprizone (a neurotoxin that induces multiple sclerosis like lesion in rat model) or large bowel resection, encephalopathies were attenuated along with gastrointestinal, liver and vascular injuries
GLP-1 receptors are found in the brain, and GLP-1 signaling may influence appetite, glucose regulation, inflammation, vascular function, and possibly neuronal stress pathways
doi:10.1177/15648265080292S107