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Additionally, the cagrisema treatment group's glycosylated hemoglobin (HbA1c) levels decreased more than those treated solely with semaglutide 2.4 mg or cagrilintide 2.4 mg alone, with reductions of -2.2%, -1.8%, and -0.9% respectively
Consequently, dual GLP-1/glucagon agonists survodutide, and triple GLP-1/GIP/glucagon agonists retatrutide are not spared gastrointestinal adverse events, as glucagon related pro-emetic signaling may offset any potential tolerability benefits from GIP agonism ( The contribution of amylin-based therapies to gastrointestinal adverse events remains less clear
Different mechanisms
Side effects are rare but may include temporary scalp sensitivity or minor irritation
Hallen-Adams, H
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