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doi: 10.1016/j.carbpol.2025.124059

Furthermore, GLP-1R can also become internalized in response to GLP-1 and its analogs, indicating a complex regulatory mechanism that affects gene expression and protein activity [32]

Some patients continue GLP-1 therapy long-term at a maintenance dose to support sustained weight loss

The theoretical 3-8% additional weight loss from adding cagrilintide to tirzepatide doesn't justify the significantly amplified side effects, 2-3x higher cost ($1,200-2,400 monthly), lack of physician support for experimental protocols, and unknown long-term safety profile

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