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The most potent synergistic effect was observed on collagen IV, with a 25.4-fold increase in cell tests and a 2.03-fold increase in ex-vivo skin tests at a 1:9 ratio of GHK-Cu to LMW HA

In the context of impaired renal function, such as occurs in chronic kidney disease and during aging, prostaglandins play an important role in the maintenance of blood flow through the kidneys

Garrote et al., 2010

In contrast, FOXO4-DRI treatment significantly reduced the cell number in the PDL9 group (Supplementary Figures 1, 2)