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Tirzepatide, the active compound in Zepbound, works by activating two hormone pathways that regulate appetite and blood sugarthe GLP-1 and GIP receptors

Patients start at 0.6 mg daily during week one

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Stress and lifestyle: Elevated cortisol inhibits melanocortin signaling, while poor sleep or inactivity reduces precursor availability for neurotransmitters like dopamine, essential for motivation