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Originally developed to manage type 2 diabetes and obesity, GLP-1 RAs are showing unexpected promise in reducing inflammation, slowing kidney damage, and protecting against cardiovascular risks in lupus patients

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Moreover, it increases intracellular cysteine levels and N -acetylcysteine, shifting melanogenesis from eumelanin to pheomelanin

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Accordingly, ablating pre- and post-ganglionic sympathetic intestinofugal neurons prevents the effects of ileal GLP-1 on stomach dilation and food intake [39]