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Both doses were safe and well tolerated, but the high-dose regimen achieved markedly higher plasma concentrations and produced a faster, greater reduction in SOFA scores and inflammatory biomarkers (CRP and procalcitonin), while preventing thrombomodulin elevation (Fowler et al., 2014)

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Starting with a lower amount and gradually increasing it is a common, cautious approach

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10.1016/j.biopha.2018.10.034 14 ClabaultH.CohenM.VaillancourtC.SandersonJ