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NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model
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The limitations of this study include a short study period, lack of follow-up, lack of measurement of serum glutathione levels and the choice of cohort, which consisted of a young and healthy population
Finally, most patients could develop a tolerance mechanism to reduce or eliminate the GLP-1RAs-induced adverse reactions (182), thus allowing their use as drugs of choice for the treatment of obesity
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