However, if the defenses are too weak, then infections cannot be handled or body cells can proliferate uncontrolled and grow to form tumors, which can become life threatening. In vivo, T-cell-specific ablation of murine Gclc prevented autoimmune disease but blocked antiviral defense, the Immunity article noted
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With the help of selenium and alpha-lipoic acid, antioxidant networks get even stronger
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Mol Pharmacol 46:909914 Kim SK, Woodcroft KJ, Khodadadeh SS, Novak RF (2004) Insulin signaling regulates gamma-glutamylcysteine ligase catalytic subunit expression in primary cultured rat hepatocytes