Antibiotic perturbation of the murine gut microbiome enhances the adiposity, insulin resistance, and liver disease associated with high-fat diet
Prajjwal P, Marsool MD, Inban P, Sharma B, Asharaf S, Aleti S, Gadam S, Al Sakini AS, Hadi DD (2023) Vascular dementia subtypes, pathophysiology, genetics, neuroimaging, biomarkers, and treatment updates along with its association with Alzheimers dementia and diabetes mellitus
Diabetologia 58(3):429442
PMID 8784838
MSDC-0602K is a second-generation thiazolidinedione designed to preferentially suppress the mitochondrial pyruvate carrier while minimizing direct binding to PPAR
A variant in for instance, might suggest differential sensitivity to GLP-1 monotherapy versus dual-compound therapy, but individual response is also shaped by lifestyle, metabolism, and comorbidities