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Fumarate hydratase deficiency Fumarate hydratase deficiency (FMRD) is a rare autosomal recessive disorder of organic acid metabolism caused by a genetic variant in the FH gene, locating on chromosome 1q42.1 [81]

Ultimately, the decision to continue or discontinue GLP-1 therapy should be individualized, considering treatment response, tolerability, patient preferences, cost, and overall health status

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Avoid doubling doses, as this increases the risk of gastrointestinal adverse effects without improving efficacy

Microdosing these medications may carry several potential risks, including reduced efficacy and unforeseen side effects

GLP-1 receptor agonists slow gastric emptying, reduce appetite, and alter gut motility