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biochemically, there is intracellular glutathione (GSH) depletion and decreased activity of glutathione peroxidase 4 (GPX4), lipid peroxides cannot be metabolized by the GPX4-catalyzed reduction reaction, and Fe 2+ oxidizes lipids in a Fenton-like manner, resulting in a large amount of ROS, which promotes ferroptosis 3,6

However, injections are much more efficient for a number of reasons: Higher Absorption Rate : B12 Injections directly bypass the digestive system so that the Vitamin B12 gets absorbed by the body as efficiently as possible