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Although the high dose (15 mg/kg) was used to indicate the effect of cyclosporine treated rats, rather than the actual dose used for humans (2.5 mg/kg), results demonstrate that cyclosporine medication can harm liver function and cause oxidative stress and redox imbalances in rat hepatocytes ( The mechanism by which cyclosporine induces oxygen species As a potent immunosuppressant, the major therapeutic effect of cyclosporine is the suppression of T-cell activity

PMID: 16056068

The schedule starts with daily shots for a week, then weekly for a month, and then monthly to keep it up

Methods (San Diego, Calif.) , 25(4)402408 doi: 10.1006/meth.2001.1262 30 LushchakV

Revel M, Chtel A, Mouneyrac C

International journal of endocrinology