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Mayo Clinic notes that there is no solid proof B12 injections help with weight loss in people who are not deficient

Long-term untreated vegan diet where deficiency has progressed beyond what oral replacement can comfortably catch up

Avoid using GLP-1 RAs if you have a personal or family history of medullary thyroid carcinoma or MEN2 syndrome (Multiple endocrine neoplasia type 2 syndrome)