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Spevaks takeaway
Since both drugs activate the GLP-1 receptor, patients with less favorable variants in this gene may have a biological ceiling that limits response to the entire class
Recently, some emerging evidence has suggested a possible association between low peripheral serotonin and fatigue
Jones KL, Huynh LQ, Hatzinikolas S, et al
This Review profiles established and emerging GLP-1-based medicines, discussing optimization of pharmacokinetics and tolerability, engagement of new therapeutically useful pathways and safety aspects
Excellent outcomes are possible with appropriate treatment (08)
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