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NNMT is an enzyme linked to cell metabolism and nicotinamide-related pathways

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The mechanistic plausibility is strong (NNMT inhibition increases NAD+ without the gastrointestinal side effects of high-dose nicotinamide), and the short-term tolerability profile is excellent, but we mean this sincerely: if you're using this compound for durations beyond what the published trials covered, you are operating in uncharted territory

Ross, A

Anyone pregnant, breastfeeding, or with a diagnosed metabolic, hepatic, or endocrine condition falls entirely outside any studied context and should not be a subject of self-directed use

This helps reduce GI side effects such as nausea, vomiting, constipation, and diarrhea