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Finally, in vitro work has looked at cellular signaling downstream of 3-AR engagement, providing mechanistic support for the lipolysis-without-hyperglycemia profile that investigators consistently observe

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In peripheral nerves, the preferential effect on small, myelinated fibers accounts for the characteristic order of sensory loss (pain, temperature, touch, proprioception) followed by motor blockade

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Laboratory investigations primarily focus on its influence over fibroblast activity, collagen type I synthesis, and the physiological signaling pathways within isolated follicle cell cultures

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis