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One cause of such a cytokine storm is an imbalance of the ratio between ACE1 (the pro-inflammatory mediator) and ACE2 (the anti-inflammatory mediator)

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The study indicated that the treatment of low dose selenite led to a just marginal increase in GPx activity in NIH3T3, MCF-7, and Sup-T1 cells, whereas identical treatment led to ~ fivefold increase of GPx activity in PC12 and AA8 cells