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Used propensity score matching to form two patient cohorts (GLP-1 users vs nonusers), each consisting of 38,439 patients

( A ) ATP generation and ( B ) intracellular cAMP accumulation were analyzed as detailed in the Supplemental Methods from WT sAC +/+ caSMCs incubated for 10 minutes with 0.1 nM to 1 M GLP-1(2836) or scrambled control

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L2-Cmu does not perturb glucose homeostasis in older mice We then evaluated effects of chronic IGF-1R mAb treatment on energy and glucose homeostasis in an initial cohort of older mice

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