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R Substrates acetylated by NATs include: Aromatic amine carcinogens (beta-naphthylamine, 4-aminobiphenyl, benzidine) Caffeine (partially, via NAT2) Dapsone Hydralazine Isoniazid (tuberculosis drug) Para-aminosalicylic acid (PABA) Procainamide Sulfonamide antibiotics Acetylation can also produce bioactivation

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Alternatively, oral capsules are available but have significantly lower bioavailability

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