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This medicine is also used to lower the risk of hospitalization for angina and heart surgery (eg, coronary revascularization) in patients with recently documented coronary artery disease (CAD) by angiography and without certain heart problems (eg, heart failure or an ejection fraction less than 40%)

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The FDA requires this warning based on animal data, and notes that it is unknown whether these medications cause thyroid C-cell tumors, including medullary thyroid carcinoma, in humans

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