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This is because much of the antioxidant is destroyed during the digestive process

If a significant part of this mechanism relies on re-absorption from bile that would be an issue due to lack of intrinsic factor breaking the "enterohepatic recirculation"

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doi: 10.3389/fimmu.2013.00470 54 De CandiaP.PrattichizzoF.GaravelliS.MatareseG

Therefore, direct measurement requires that the IGF-1/IGFBP complex be disrupted