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Weight Loss Both semaglutide and liraglutide work by activating GLP-1 receptors in the brain, which helps to: Suppress appetite Increase satiety Decrease caloric intake Increase thermogenesis In clinical studies, individuals with obesity or overweight who took either medication experienced significant reductions in body weight compared to those who received a placebo [2, 10]

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J Biol Chem (1997) 272(43):2721823