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Early escalation can trigger severe nausea, vomiting, and gastrointestinal distress that may force treatment discontinuation altogether

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Seek urgent medical assessment if you experience signs of anaphylaxis (difficulty breathing, facial swelling), widespread rash with fever, or severe unrelenting pain

Moreover, in addition to showing the direct inhibition of GAPDH by oxidation, the authors demonstrated that its activity is further hindered by DHA-induced NAD + depletion, since GAPDH activity relies on the availability of NAD + as a co-substrate

According to the Wegovy Summary of Product Characteristics (SmPC), treatment should be discontinued if a patient has not lost at least 5% of their initial body weight after 12 weeks on the maintenance dose (2.4 mg once weekly)