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This finding is consistent with leading CKD treatment guidelines, where SGLT2is are recommended as first line in addition to RAS inhibition, metformin and statins [2, 7], and reflects the breadth of pivotal trial data (DAPA-CKD, EMPA-KIDNEY and CREDENCE) demonstrating earlier kidney and cardiovascular benefits (e.g

MTHFR supports methylation, and methylation is crucial for the production of energy, including the synthesis of carnitine